Long Tang , Xi Chen , Xiang-ming Kong , Tian-wen Liu , Xiao-qing Feng , Fen-er Chen , Zi-heng Zhuang
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引用次数: 1
Abstract
At present, the global irreversible rapid population aging will cause serious social healthcare burden and economic downward pressure for many countries or regions. Urolithin A (UA) has received extensive attention and research due to its role in inducing mitophagy and improving muscle capacity. Methylurolithin A (mUA) and its nine amide derivatives were synthesized in this study in order to find potential drugs with better anti-aging effects. The anti-aging and biosafety of the synthesized compounds were evaluated using Caenorhabditis elegans (C. elegans). The results showed that among mUA and its nine amide derivatives, Cpd. 6 had the best anti-aging effect, and had good biosafety in the growth, reproduction and motility of C. elegans. Therefore, we believe that Cpd. 6 is most suitable to be considered as a potential anti-aging drug for further development and investigation.
当前，全球不可逆转的人口快速老龄化将给许多国家或地区带来严重的社会医疗负担和经济下行压力。尿素A (urolitin A, UA)因其在诱导线粒体自噬和提高肌肉能力方面的作用而受到广泛关注和研究。为了寻找具有较好抗衰老作用的潜在药物，本研究合成了methylurolitin A (mUA)及其9个酰胺类衍生物。利用秀丽隐杆线虫(C. elegans)对合成的化合物进行抗衰老和生物安全性评价。结果表明，在mUA及其9个酰胺类衍生物中，Cpd. 6的抗衰老效果最好，对秀丽隐杆线虫的生长、繁殖和活动具有良好的生物安全性。因此，我们认为Cpd. 6最适合作为一种潜在的抗衰老药物进行进一步的开发和研究。
期刊介绍：
Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.
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