Amino acid transport by the small intestine of the rat on the counterflow phenomenon as a cause of the accelerating effect of leucine on the transintestinal transport of diamino acids

B.G. Munck
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引用次数: 33

Abstract

The accelerating effect of leucine on the transintestinal transport of lysine has been studied.

The relationship of the transport of lysine to that of leucine was such as would be expected if the accelerating effect of leucine was a result of the combined function of the transport mechanisms of the neutral and the diamino acids. Of the two transport mechanisms that of the neutral amino acids created and maintained, on the serosal side of the transport mechanisms, a concentration of leucine sufficient to exert a counterflow effect on the transport of lysine by the transport mechanism of the diamino acids.

The transintestinal transport of arginine and ornithine was accelerated by leucine to the same extent as that of lysine.

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氨基酸在大鼠小肠转运中的逆流现象是亮氨酸对二氨基酸跨肠转运的加速作用的一个原因
研究了亮氨酸对赖氨酸经肠转运的加速作用。如果亮氨酸的加速作用是中性酸和二氨基酸运输机制共同作用的结果,那么赖氨酸和亮氨酸的运输关系是可以预料的。在中性氨基酸的两种转运机制中,在转运机制的浆膜一侧,产生并维持了足够的亮氨酸浓度,以通过二氨基酸的转运机制对赖氨酸的转运施加逆流效应。亮氨酸对精氨酸和鸟氨酸的肠内转运有与赖氨酸相同的促进作用。
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Subject index Author index The conformation of eye-lens proteins studied by means of optical rotatory dispersion Membrane ATPase and electrolyte levels in marsupial erythrocytes Conformational change accompanying modification of myosin ATPase
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