{"title":"A speculation on the origin of the genetic code","authors":"D.C. Reanney, R.K. Ralph","doi":"10.1016/0022-5193(67)90042-2","DOIUrl":null,"url":null,"abstract":"<div><p>It is proposed that deoxyuridylic acid and deoxyinosinic acid were the original monomeric precursors of primordial polynucleotides. As such, deoxyuridylic acid mimicked deoxycytidylic acid, while deoxyinosinic acid mimicked deoxyguanylic and deoxyadenylic acid. The implications of this possibility for the evolution of the genetic code are explored. The hypothesis provides a satisfactory explanation for (a) the origin of unbranched, linear and cyclic polynucleotides; (b) the essentially doublet nature of the code; (c) the present pattern of degeneracy in the code; (d) the existence of relationships between some amino acids and their codons.</p></div>","PeriodicalId":54763,"journal":{"name":"Journal of Theoretical Biology","volume":"15 1","pages":"Pages 41-52"},"PeriodicalIF":2.0000,"publicationDate":"1967-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0022-5193(67)90042-2","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Theoretical Biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0022519367900422","RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 6
Abstract
It is proposed that deoxyuridylic acid and deoxyinosinic acid were the original monomeric precursors of primordial polynucleotides. As such, deoxyuridylic acid mimicked deoxycytidylic acid, while deoxyinosinic acid mimicked deoxyguanylic and deoxyadenylic acid. The implications of this possibility for the evolution of the genetic code are explored. The hypothesis provides a satisfactory explanation for (a) the origin of unbranched, linear and cyclic polynucleotides; (b) the essentially doublet nature of the code; (c) the present pattern of degeneracy in the code; (d) the existence of relationships between some amino acids and their codons.
期刊介绍：
The Journal of Theoretical Biology is the leading forum for theoretical perspectives that give insight into biological processes. It covers a very wide range of topics and is of interest to biologists in many areas of research, including:
• Brain and Neuroscience
• Cancer Growth and Treatment
• Cell Biology
• Developmental Biology
• Ecology
• Evolution
• Immunology,
• Infectious and non-infectious Diseases,
• Mathematical, Computational, Biophysical and Statistical Modeling
• Microbiology, Molecular Biology, and Biochemistry
• Networks and Complex Systems
• Physiology
• Pharmacodynamics
• Animal Behavior and Game Theory
Acceptable papers are those that bear significant importance on the biology per se being presented, and not on the mathematical analysis. Papers that include some data or experimental material bearing on theory will be considered, including those that contain comparative study, statistical data analysis, mathematical proof, computer simulations, experiments, field observations, or even philosophical arguments, which are all methods to support or reject theoretical ideas. However, there should be a concerted effort to make papers intelligible to biologists in the chosen field.
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