A clinical trial of live attenuated varicella vaccine (Biken) in children with malignant diseases.

Biken journal Pub Date : 1984-09-01
T Konno, Y Yamaguchi, M Minegishi, Y Goto, S Tsuchiya
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Abstract

The live attenuated varicella vaccine (Biken) derived from the Oka strain was used for immunization of childhood cancer patients in remission but on chemotherapy. Thirty nine patients were immunized without any severe adverse effects but 6 recipients had a small number of vesicles. Seroresponses were observed in 90% of recipients examined. During the follow-up period 6 leukemia recipients were suffered from natural varicella in family or community contacts. No vaccinee developed herpes-zoster during this study period.

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儿童恶性疾病减毒水痘活疫苗(Biken)的临床试验。
从Oka毒株衍生的减毒水痘活疫苗(Biken)用于儿童癌症缓解但化疗患者的免疫接种。39例接种者无严重不良反应,6例接种者出现少量水疱。90%的受检者均有血清反应。随访期间,有6例白血病患者在家庭或社区接触者中感染水痘。在此研究期间,没有接种疫苗的人患带状疱疹。
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