Prevention of varicella in immunocompromised patients on unpredictable occurrence of the disease in a children's ward: vaccine-boostered immune whole blood transfusion (VIB) method.

Abstract

For prevention of secondary varicella infection in patients whose immunities were extremely impaired by intensive chemotherapy or immunosuppressive agents, we have been using the vaccine-boostered immune whole blood transfusion (VIB) method when there was an unpredictable case of varicella in the children's ward. By this method passive transfer of humoral and cellular immunity is achieved. There have been 25 unpredictable occurrences of varicella or herpes-zoster in the ward of our children's hospital between April 1977 and May 1983 and during these episodes 16 patients, mostly with malignant diseases, have been treated by this method. There has been no case of secondary varicella infection among these patients and no serious troubles associated with the VIB method.