Propranolol (inderal) for tardive dyskinesia and extrapyramidal side effects from neuroleptics: Possible involvement of beat - adrenergic mechanisms

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI:10.1016/0364-7722(81)90105-3

Robert Wilbur , Frank A Kulik

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引用次数: 19

Abstract

1.
1. This clinical report describes four psychotic patients with neuroleptic-induced tardive (orofacial) dyskinesia and extrapyramidal side effects who were successfully treated with propranolol 30 – 60 mg per day.
2.
2. Relief of orofacial symptoms and tremor was marked and rapid (one to ten days). In one case propranolol was stopped and orofacial symptoms emerged.
3.
3. No side effects were observed.
4.
4. The literature on propranolol in tardive dyskinesia and tremor disorders is reviewed. Central and peripheral mechanisms are considered, and several specific experiments are proposed to clarify the site of action. It is suggested that clinical investigation with propranolol in tardive dyskinesia and extrapyramidal side effects might enhance our understanding of the possible adrenergic modulation of the dopaminergic/cholinergic balance in the striatum.

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心得安治疗迟发性运动障碍和抗精神病药的锥体外系副作用:可能与肾上腺素能机制有关

1.1. 本临床报告描述了4例精神病患者，他们患有抗精神病药引起的迟发性(口面部)运动障碍和锥体外系副作用，并成功地每天服用30 - 60mg心得安。口面部症状和震颤的缓解明显而迅速(1至10天)。1例停用心得安后出现口面部症状。未见副作用。综述了心得安治疗迟发性运动障碍和震颤障碍的文献。考虑了中枢和外周机制，并提出了几个具体的实验来阐明作用部位。提示应用心得安治疗迟发性运动障碍和锥体外系副作用的临床研究可能有助于我们了解肾上腺素能调节纹状体中多巴胺能/胆碱能平衡的可能性。

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