[11C-Ro15-1788 and 11C-flunitrazepam, two coordinates for the study by positron emission tomography of benzodiazepine binding sites].

M Mazière, C Prenant, J Sastre, M Crouzel, D Comar, P Hantraye, M Kaïsima, B Guibert, R Naquet
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Abstract

In vivo binding of a benzodiazepine (flunitrazepam-C11) and a benzodiazepine antagonist (Ro 15-1788-C11) were studied with positron emission tomography. Advantages and disadvantages of each drug for studying specific in vivo binding sites are presented. The results obtained indicate that Ro 15-1788-C11 is a better in vivo radiocoordinat than flunitrazepam-C11.

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[11C-Ro15-1788和11c -氟硝西泮,两个坐标用于苯二氮卓类药物结合位点的正电子发射断层扫描研究]。
用正电子发射断层扫描研究了苯二氮卓类药物(氟硝西泮- c11)和苯二氮卓类拮抗剂(Ro 15-1788-C11)的体内结合。介绍了每种药物在研究体内特异性结合位点方面的优缺点。结果表明,ro15 -1788- c11是比氟硝西泮- c11更好的体内放射配位剂。
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