Theoretical simulation of a model describing hormone receptor--adenylate cyclase coupling.

Abstract

We have shown that current knowledge of the coupling between receptor and cyclase, as expressed in terms of the proposed model, can account for the nonlinear coupling between cyclase activation by hormone and receptor-occupancy, and for the effects of GTP on hormone-binding. Such demonstrations require mathematical analysis and numerical simulation. The results can be used as theoretical support for intuitive interpretations of observed behavior and can predict consequences of variations in the concentration of the elements of the system (R, G, E).