{"title":"Role of activated protein C on platelet aggregation induced by thrombin.","authors":"E Novoa Santander, L Derpich Miranda","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Platelets aggregate with thrombin-free activated protein C in concentrations higher than physiological levels. Aggregation was dependent on an intact release mechanism since inhibition of aggregation occurred with adenosine or EDTA. However, activated protein C reduced the sensitivity of platelets to aggregate in the presence of thrombin. Probably, activated protein C competes for membrane sites sensitive to thrombin.</p>","PeriodicalId":7131,"journal":{"name":"Acta physiologica latino americana","volume":"33 2","pages":"161-4"},"PeriodicalIF":0.0000,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta physiologica latino americana","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Platelets aggregate with thrombin-free activated protein C in concentrations higher than physiological levels. Aggregation was dependent on an intact release mechanism since inhibition of aggregation occurred with adenosine or EDTA. However, activated protein C reduced the sensitivity of platelets to aggregate in the presence of thrombin. Probably, activated protein C competes for membrane sites sensitive to thrombin.
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