W Ihn, C Wagner, W F Fleck, D Tresselt, I Eritt, P Sedmera
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引用次数: 8
Abstract
Various blocked mutants were isolated from three leukaemomycin-(daunomycin-)producing strains IMET JA 3933, IMET JA 5142 and IMET JA 5570 of Streptomyces griseus by NTG and UV treatments. Among them, one class of four mutants ZIMET 43707/1P, IMET JA 5570/3P, IMET JA 5570/10P and IMET JA 5142/01P1 produced new blue and red pigments. Two red compounds designated 1PI and 1PII are the main components of the pigment complex produced by culture of the blocked mutant ZIMET 43707/1P. This paper describes the isolation of 1PI and IPII; furthermore, the spectral and physicochemical properties of these anthracyclinones and the elucidation of their structures are reported.
通过NTG和UV处理，从灰色链霉菌的3株产白霉素(道诺霉素)菌株IMET JA 3933、IMET JA 5142和IMET JA 5570中分离出多种阻断突变体。其中，一类4个突变体ZIMET 43707/1P、IMET JA 5570/3P、IMET JA 5570/10P和IMET JA 5142/01P1产生了新的蓝色和红色色素。两种被命名为1PI和1PII的红色化合物是阻断突变体ZIMET 43707/1P培养产生的色素复合物的主要成分。本文介绍了1PI和IPII的分离;此外，还报道了这些蒽环类化合物的光谱和理化性质，并对它们的结构进行了说明。
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