Xenogeneic transplantation of human tumors of the gastro-intestinal tract in nude mice

Abstract

The transplantation of human adenocarcinomas of the gastrointestinal tract into nude mice is described. The human primary tumors were located in the stomach, colon or rectum. Successively transplantable lines could be established by means of implantations of tumor blocks in the left abdominal wall of nude mice. Some biological and histopathological criteria of the implanted tumors as compared to their human origins are given. Several experiments concerning the dependence of tumor growth in nude mice upon the region of implantation are reported. Moreover, first results with regard to development of tumor recidives in nude mice after resection are presented.