{"title":"Effect of parachlorophenylalanine on the incidence of abnormal behaviors observed following diazepam withdrawal","authors":"Tsutomu Suzuki , Toshio Yoshii , Saizo Yanaura , Ryuji Fukumori , Tetsuo Satoh , Haruo Kitagawa","doi":"10.1016/0364-7722(81)90094-1","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. Rats were rendered dependent on diazepam by administrating escalating dosages of diazepam in diet.</p></span></li><li><span>2.</span><span><p>2. At the time of diazepam withdrawal, the animals were treated with parachlorophenylalanine (PCPA), a potent serotonin (5-HT) depleter, or the corresponding vehicle.</p></span></li><li><span>3.</span><span><p>3. After diazepam withdrawal, PCPA-treated animals showed abnormal behaviors, such as aggression, irritability, vocalization and muscular rigidity.</p></span></li><li><span>4.</span><span><p>4. In contrast, little or no changes in behavior were observed in control animals.</p></span></li><li><span>5.</span><span><p>5. These results suggest that depletion of brain 5-HT by PCPA potentiates diazepam withdrawal signs.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90094-1","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in neuro-psychopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0364772281900941","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
1.
1. Rats were rendered dependent on diazepam by administrating escalating dosages of diazepam in diet.
2.
2. At the time of diazepam withdrawal, the animals were treated with parachlorophenylalanine (PCPA), a potent serotonin (5-HT) depleter, or the corresponding vehicle.
3.
3. After diazepam withdrawal, PCPA-treated animals showed abnormal behaviors, such as aggression, irritability, vocalization and muscular rigidity.
4.
4. In contrast, little or no changes in behavior were observed in control animals.
5.
5. These results suggest that depletion of brain 5-HT by PCPA potentiates diazepam withdrawal signs.
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