Comparative study of oltipraz versus praziquantel for treatment of schistosomiasis with intestinal manifestation in the Gabon (Schistosoma intercalatum and S. haematobium).
{"title":"Comparative study of oltipraz versus praziquantel for treatment of schistosomiasis with intestinal manifestation in the Gabon (Schistosoma intercalatum and S. haematobium).","authors":"P Kern, G D Burchard, M Dietrich","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>158 school children from Lambarene and its surroundings suffering from intestinal manifestations of schistosomiasis due to Schistosoma intercalatum, Schistosoma haematobium, or mixed infections were randomly allocated to patient groups to be treated with oltipraz and praziquantel respectively. Oltipraz was tested in three dosage regimens, i.e., 1 X 25 mg/kg, 1 X 35 mg/kg, and 2 X 20 mg/kg and compared to 2 X 30 mg/kg praziquantel in each of the treatment groups. 45 days and 90 days after treatment, the children were thoroughly investigated. Rectoscopy was only performed in part of the children. The number of children with viable egg excretion had significantly dropped after therapy (p less than 0.001). Parasitological cure after 90 days was obtained in 86% of patients treated with 2 X 20 mg oltipraz and 90% of patients treated by praziquantel. A comparative effectiveness was achieved with the other dosage regimens of oltipraz, too. The efficacy of the new schistosomicid oltipraz is identical with that of praziquantel for patients with intestinal manifestation. The rectal biopsies taken 45 days and 90 days after therapy still contained numerous eggs which were mostly calcified or granulated.</p>","PeriodicalId":76764,"journal":{"name":"Tropenmedizin und Parasitologie","volume":"35 2","pages":"95-9"},"PeriodicalIF":0.0000,"publicationDate":"1984-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tropenmedizin und Parasitologie","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
158 school children from Lambarene and its surroundings suffering from intestinal manifestations of schistosomiasis due to Schistosoma intercalatum, Schistosoma haematobium, or mixed infections were randomly allocated to patient groups to be treated with oltipraz and praziquantel respectively. Oltipraz was tested in three dosage regimens, i.e., 1 X 25 mg/kg, 1 X 35 mg/kg, and 2 X 20 mg/kg and compared to 2 X 30 mg/kg praziquantel in each of the treatment groups. 45 days and 90 days after treatment, the children were thoroughly investigated. Rectoscopy was only performed in part of the children. The number of children with viable egg excretion had significantly dropped after therapy (p less than 0.001). Parasitological cure after 90 days was obtained in 86% of patients treated with 2 X 20 mg oltipraz and 90% of patients treated by praziquantel. A comparative effectiveness was achieved with the other dosage regimens of oltipraz, too. The efficacy of the new schistosomicid oltipraz is identical with that of praziquantel for patients with intestinal manifestation. The rectal biopsies taken 45 days and 90 days after therapy still contained numerous eggs which were mostly calcified or granulated.
将158名兰巴伦市及周边地区因卡间血吸虫病、血血吸虫病或混合感染而出现血吸虫病肠道表现的学龄儿童随机分为患者组,分别给予奥替普拉和吡喹酮治疗。Oltipraz在三种剂量方案中进行了测试,即1 X 25mg /kg、1 X 35mg /kg和2 X 20mg /kg,并在每个治疗组中与2 X 30mg /kg吡喹酮进行了比较。治疗后45天和90天,对患儿进行全面调查。仅部分患儿行直肠镜检查。治疗后,有活卵排泄的患儿数量显著下降(p < 0.001)。用2x20mg奥替普拉治疗的患者在90天后获得了86%的寄生虫学治愈,用吡喹酮治疗的患者在90天后获得了90%的寄生虫学治愈。与奥替普拉茨的其他剂量方案也取得了比较效果。新型血吸虫药奥替praz与吡喹酮对有肠道表现的患者疗效相同。治疗后45天和90天的直肠活检仍含有大量的卵,多数为钙化或颗粒状。