Demonstration of carcinogenicity in F344 rats of 2-amino-3-methyl-imidazo[4,5-f]quinoline from broiled sardine, fried beef and beef extract.

Gan Pub Date : 1984-06-01
S Takayama, Y Nakatsuru, M Masuda, H Ohgaki, S Sato, T Sugimura
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Abstract

The mutagenic compound 2-amino-3-methylimidazo[4,5-f]quinoline, originally isolated from broiled sardines and also present in cooked beef and beef extract, is being tested for carcinogenicity in F344 rats of both sexes. High incidences of tumors of the Zymbal gland, colon, small intestine and liver in males have been observed in the first 300 days of the experiment.

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从烤沙丁鱼、煎牛肉和牛肉提取物中提取的2-氨基-3-甲基-咪唑[4,5-f]喹啉对F344大鼠的致癌性证明。
致突变化合物2-氨基-3-甲基咪唑[4,5-f]喹啉最初是从烤沙丁鱼中分离出来的,也存在于煮熟的牛肉和牛肉提取物中,目前正在F344雄性和雌性大鼠身上进行致癌性测试。在实验开始的前300天,观察到男性的淋巴腺、结肠、小肠和肝脏肿瘤的高发病率。
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