Rapid modulation of platelet aggregation in plasma by oxygenated sterols.

Journal of applied biochemistry Pub Date : 1984-06-01
H Shimada, T Imada, T Kikuchi, Y Inada, M Morisaki, N Ikekawa, Y Saito
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Abstract

The effect of oxygenated sterols on platelet aggregation induced by thrombin and ADP has been studied. All oxygenated sterols tested with a hydroxyl group on the side chain enhanced thrombin-induced aggregation at 25 microM. In the case of ADP-induced aggregation, however, only 22S-hydroxycholesterol[(22S)-5-cholestene-3 beta,22-diol] enhanced the aggregation, and 22R-hydroxycholesterol[(22R)-5-cholestene-3 beta,22-diol], 24S-hydroxycholesterol[(24S)-5-cholestene-3 beta,24-diol], and 25-hydroxycholesterol[5-cholestene-3 beta,25-diol] inhibited it. These effects were observed within 10 min after the addition of oxygenated sterols to platelet suspensions in plasma.

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氧合甾醇对血浆血小板聚集的快速调节。
研究了氧合甾醇对凝血酶和ADP诱导的血小板聚集的影响。所有在侧链上有羟基的氧化甾醇在25微米时都增强了凝血酶诱导的聚集。然而,在adp诱导的聚集情况下,只有22S-羟基胆固醇[(22S)-5-胆固醇-3 β,22-diol]增强了聚集,而22R-羟基胆固醇[(22R)-5-胆固醇-3 β,22-diol], 24S-羟基胆固醇[(24S)-5-胆固醇-3 β,24-diol]和25-羟基胆固醇[5-胆固醇-3 β,24-diol]抑制了聚集。这些效果是在向血浆血小板混悬液中加入氧合甾醇后10分钟内观察到的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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