Temporal changes in liver, blood, and brain glucose, glycogen, and beta-hydroxybutyrate after ethanol in C57BL/6J mice.

Substance and alcohol actions/misuse Pub Date : 1984-01-01
R A Schreiber, A L Ungar
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Abstract

The time courses of changes in levels of beta-hydroxybutyrate (BOHB), glucose (GLC), and glycogen (GLY) were measured hourly for 7 h after i.p. 2 g/kg ethanol (ETOH) in samples of liver, blood, and brain in 21 day old C57BL/6J mice. After acute ETOH, brain GLC remained at 2.1 mmol/kg for 2 h, fell to a low of 1.5 mmol/kg at 5 h, then rose slightly. Blood GLC remained near 8 mmol/kg until 3 h, then fell. Liver GLC fell steadily from 10.2 to 7.2 mmol/kg at 7 h. Brain GLY rose from 1.7 to 2.9 mmol/kg at 3 h, then fell steadily. Blood GLY increased from 2.7 to 4.6 mmol/kg at 2 h, then fell to 1.7 mmol/kg. Liver GLY decreased from 70 to 30 mmol/kg. BOHB changes were similar in all samples. BOHB in brain fell from 0.12 to 0.08 mmol/kg at 2 to 3 h; then rose steadily to 0.27 mmol/kg at 7 h. Blood and liver BOHB fell from 0.40 to 0.25 mmol/kg, then rose to 1.0 mmol/kg. In a previous study, susceptibility to audiogenic seizures after 2 g/kg ETOH was completely suppressed for up to 1 h, then susceptibility increased to a maximum at 5 1/2 h, when a period of potentiation was observed. In this study, brain GLY levels were increased during the period of protection, and brain GLC levels were decreased during the period of potentiation. Together, these data may lend support to an hypothesis of an indirect effect of ETOH on the brain, leading to changes in susceptibility to audiogenic seizures via changes in metabolite availability.

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C57BL/6J小鼠经乙醇处理后肝脏、血液和脑葡萄糖、糖原和β -羟基丁酸酯的时间变化。
在21日龄C57BL/6J小鼠的肝脏、血液和脑样品中,每小时注射2 g/kg乙醇(ETOH) 7 h,测量β -羟基丁酸(BOHB)、葡萄糖(GLC)和糖原(GLY)水平变化的时间过程。急性ETOH后,脑GLC维持在2.1 mmol/kg 2 h, 5 h降至1.5 mmol/kg的低点,随后略有上升。血GLC维持在8 mmol/kg附近,3 h后下降。肝GLC在7 h时由10.2降至7.2 mmol/kg,脑glly在3 h时由1.7上升至2.9 mmol/kg,随后稳定下降。血液GLY在2 h时由2.7升高至4.6 mmol/kg,随后降至1.7 mmol/kg。肝脏GLY从70 mmol/kg降至30 mmol/kg。所有样本的BOHB变化相似。脑BOHB在2 ~ 3 h由0.12降至0.08 mmol/kg;血液和肝脏BOHB由0.40降至0.25 mmol/kg,再上升至1.0 mmol/kg。在先前的研究中,2 g/kg ETOH对听源性癫痫的易感性在1小时内被完全抑制,然后在5 1/2小时时易感性增加到最大值,这时观察到一段增强期。在本研究中,脑glly水平在保护期升高,脑GLC水平在增强期降低。综上所述,这些数据可能支持一种假说,即ETOH对大脑有间接影响,通过改变代谢物的可用性,导致对听源性癫痫的易感性发生变化。
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