A case of immunodeficiency with decreased serum IgA levels and impaired polyclonal B cell differentiation in vitro.

T Sakano, A Hosokawa, N Horino, S Hyodo, T Kishi, T Suzawa, E Kittaka, N Sakura, T Usui
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Abstract

We report a patient with low serum IgA levels and persistent pulmonary infection. In spite of the normal contents of serum IgG and IgM, the patient had a deficiency for plasma cell differentiation of all major classes of immunoglobulins (IgG, IgA and IgM). Cross culture systems between normal T or B cells and the patient's T or B cells showed a defect of both T and B cell function.

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免疫缺陷伴血清IgA水平降低和体外多克隆B细胞分化受损1例。
我们报告一个低血清IgA水平和持续肺部感染的病人。患者血清IgG、IgM含量正常,但主要免疫球蛋白(IgG、IgA、IgM)均缺乏浆细胞分化。正常T细胞或B细胞与患者T细胞或B细胞的交叉培养系统显示出T细胞和B细胞功能的缺陷。
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