{"title":"A calculator package for pharmacokinetic application","authors":"P Várkonyi, Z Gabányi, T Deutsch","doi":"10.1016/0010-468X(83)90049-1","DOIUrl":null,"url":null,"abstract":"<div><p>A calculator program package is given for the computation of the parameters of two different pharmacokinetic models: the ‘one compartment open model’ with first order absorption, and the ‘two compartment open model’ with rapid intravenous injection, using the peeling method. If parameters are known, simulation of these systems can be done for single and repetitive doses. The package includes an area under curve (<em>AUC</em>) program for the evaluation of clearance. The algorithms were applied for TI 58,59 and HP 97 calculators and they can be widely used in clinical practice.</p></div>","PeriodicalId":75731,"journal":{"name":"Computer programs in biomedicine","volume":"17 3","pages":"Pages 277-282"},"PeriodicalIF":0.0000,"publicationDate":"1983-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0010-468X(83)90049-1","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Computer programs in biomedicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0010468X83900491","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6
Abstract
A calculator program package is given for the computation of the parameters of two different pharmacokinetic models: the ‘one compartment open model’ with first order absorption, and the ‘two compartment open model’ with rapid intravenous injection, using the peeling method. If parameters are known, simulation of these systems can be done for single and repetitive doses. The package includes an area under curve (AUC) program for the evaluation of clearance. The algorithms were applied for TI 58,59 and HP 97 calculators and they can be widely used in clinical practice.
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