X Ronot, D Kuch, C Hecquet, M Adolphe, P Lechat, G Deysson
{"title":"[Inhibitory effect of cytembena (sodium-cis-beta-methoxybenzoyl-beta-bromoacrylate) on the cell kinetics of HeLa cells in culture].","authors":"X Ronot, D Kuch, C Hecquet, M Adolphe, P Lechat, G Deysson","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The inhibiting effect of Cytembena on HeLa cell kinetics has been demonstrated and analyzed. The percentage of cycling cells decreases, according to the concentration, between 7.5 and 2.5 x 10(-5) M. Estimation of DNA by cell flow cytophotometry shows an important shift in the distribution of cycling cells with a relative decrease of G1 cells and a very important accumulation of G2 cells. According to our experimental conditions, the blocking up in G2 is irreversible only at 7.5 x 10(-5) M.</p>","PeriodicalId":10605,"journal":{"name":"Comptes rendus des seances de l'Academie des sciences. Serie D, Sciences naturelles","volume":"291 12","pages":"961-4"},"PeriodicalIF":0.0000,"publicationDate":"1980-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comptes rendus des seances de l'Academie des sciences. Serie D, Sciences naturelles","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The inhibiting effect of Cytembena on HeLa cell kinetics has been demonstrated and analyzed. The percentage of cycling cells decreases, according to the concentration, between 7.5 and 2.5 x 10(-5) M. Estimation of DNA by cell flow cytophotometry shows an important shift in the distribution of cycling cells with a relative decrease of G1 cells and a very important accumulation of G2 cells. According to our experimental conditions, the blocking up in G2 is irreversible only at 7.5 x 10(-5) M.
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