Differential influence of lipoproteins isolated from women and men on the activity of the PGI2 synthetase activity

Abstract

We have found a correlation between the activity of the PGI₂ synthetase in the microsomal fraction of pig aorta and the amount of high density lipoprotein (HDL) cholesterol in the incubation fluid. The reverse was true for low density lipoprotein (LDL) cholesterol. These correlations exist independently of whether the lipoproteins were isolated from men than from women as it is for HDL isolated from women than from men. This result may give an explanation for the differential risk against the incidence of cardiovascular diseases between women and men at the same concentration of the individual lipoproteins in their blood.