NCTC 1469 CB, a subline of the macrophage-like cell line NCTC 1469 with reduced phagocytic activity.

Abstract

A variant subline, NCTC 1469 CB, of the macrophage-like cell line NCTC 1469 is described. NCTC 1469 CB cells are macrophage-like cells as the cells adhere, phagocytose carbon particles, have Fc and complement receptors and high levels of lysosomal enzymes. NCTC 1469 CB cells, however, do not phagocytose erythrocytes coated with IgG and complement, while the original NCTC 1469 cells phagocytose these coated erythrocytes in large amounts. The NCTC 1469 CB cells might be interesting for the study of mechanisms of Fc- and complement-mediated processes.