Inhibition of leukocyte adherence by potassium chloride extract of allogeneic squamous cell carcinoma of the human uterine cervix.

American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction Pub Date : 1983-06-01 DOI:10.1111/j.1600-0897.1983.tb00244.x

M M Dini, L Lenzi, I Faiferman

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Abstract

Leukocyte adherence inhibition (LAI) assay was used to evaluate cell-mediated immunity in patients with invasive squamous cell carcinoma of the cervix. The reactivity of the peripheral blood leukocytes of these patients was evaluated after incubation with pooled extracts of allogeneic squamous cell carcinoma of the cervix. One hundred sixty-seven sets of LAI assays were performed on 54 individuals, including 23 patients with Stage I squamous cell carcinoma of the cervix, 9 patients with other stages of this tumor, 9 patients with unrelated tumors and 13 normal healthy volunteers. A protein concentration of one milligram per milliliter in the tumor extract and 10% fetal bovine serum in the feeding media gave the best results. Eighty-seven percent (28/32) of patients with squamous cell carcinoma of the cervix showed marked specific reactivity. No difference was found in the LAI indices of different stages of the disease.

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人子宫颈同种异体鳞状细胞癌氯化钾提取物对白细胞粘附的抑制作用。

白细胞粘附抑制(LAI)法评价宫颈浸润性鳞状细胞癌患者的细胞介导免疫。这些患者外周血白细胞的反应性在用宫颈同种异体鳞状细胞癌的混合提取物孵育后进行了评估。对54例患者进行了167组LAI检测，其中宫颈I期鳞状细胞癌患者23例，其他分期患者9例，无关肿瘤患者9例，正常健康志愿者13例。肿瘤提取物中蛋白质浓度为1毫克/毫升，饲料中添加10%的胎牛血清，效果最好。87%(28/32)的宫颈鳞癌患者表现出明显的特异性反应性。不同病期LAI指数无差异。

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American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction

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