Clinical chemical changes in physical activity.

Abstract

Physical activity intervenes in metabolism in a number of areas. The changes depend on both the degree and duration of the effort. This article describes some of the biochemical changes known to us, and which on the whole are reflected in the blood and urine. Diagnostically important enzymes, especially CK, ASAT and LD, remain significantly increased for several days after heavy exercise. Renal function is temporarily depressed. The serum levels of urea, creatinine and uric acid rise and may stay high for several days. Electrolyte disturbances and acid-base shifts are short-lived and disappear in the course of hours. Fluid balance can take two or three days to return to normal. The leucocyte and thrombocyte counts in the blood rise and the concentration of several coagulation factors increases significantly. There are in addition changes in plasma proteins. Results of a series of common clinical chemical analyses may be affected by physical activity. It is important to recognise these possibilities in order to avoid clinical misinterpretations.