Disseminated mycobacterial histiocytosis due to M. Fortuitum associated with helper T-lymphocyte immune deficiency.

B D Bültmann, H D Flad, E Kaiserling, H K Müller-Hermelink, G Kratzsch, J Galle, W Schachenmayr, H Heimpel, H J Wigger, O Haferkamp
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引用次数: 5

Abstract

Mycobacterial histiocytosis is a rare disease usually associated with haematological or immunological disorders. We report a fatal case caused by M. fortuitum infection showing the typical disseminated histiocytosis. Immunological investigations revealed impaired cellular immunity demonstrated by negative skin tests with different "recall-antigens", and in vitro an isolated defect of helper T-lymphocytes in the peripheral blood which in combination with hypergammaglobulinemia suggests a "lymphocyte and distribution syndrome".

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与辅助性t淋巴细胞免疫缺陷相关的福氏分枝杆菌弥散性组织细胞增多症。
分枝杆菌组织细胞增多症是一种罕见的疾病,通常与血液学或免疫学疾病有关。我们报告一例由偶发分枝杆菌感染引起的死亡病例,表现为典型的弥散性组织细胞增多症。免疫学调查显示,不同“回忆抗原”的皮肤试验呈阴性,表明细胞免疫受损,体外外周血中孤立的辅助性t淋巴细胞缺陷,结合高γ -球蛋白血症提示“淋巴细胞和分布综合征”。
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