B D Bültmann, H D Flad, E Kaiserling, H K Müller-Hermelink, G Kratzsch, J Galle, W Schachenmayr, H Heimpel, H J Wigger, O Haferkamp
{"title":"Disseminated mycobacterial histiocytosis due to M. Fortuitum associated with helper T-lymphocyte immune deficiency.","authors":"B D Bültmann, H D Flad, E Kaiserling, H K Müller-Hermelink, G Kratzsch, J Galle, W Schachenmayr, H Heimpel, H J Wigger, O Haferkamp","doi":"10.1007/BF00429614","DOIUrl":null,"url":null,"abstract":"<p><p>Mycobacterial histiocytosis is a rare disease usually associated with haematological or immunological disorders. We report a fatal case caused by M. fortuitum infection showing the typical disseminated histiocytosis. Immunological investigations revealed impaired cellular immunity demonstrated by negative skin tests with different \"recall-antigens\", and in vitro an isolated defect of helper T-lymphocytes in the peripheral blood which in combination with hypergammaglobulinemia suggests a \"lymphocyte and distribution syndrome\".</p>","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"395 2","pages":"217-25"},"PeriodicalIF":0.0000,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00429614","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Virchows Archiv. A, Pathological anatomy and histology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/BF00429614","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5
Abstract
Mycobacterial histiocytosis is a rare disease usually associated with haematological or immunological disorders. We report a fatal case caused by M. fortuitum infection showing the typical disseminated histiocytosis. Immunological investigations revealed impaired cellular immunity demonstrated by negative skin tests with different "recall-antigens", and in vitro an isolated defect of helper T-lymphocytes in the peripheral blood which in combination with hypergammaglobulinemia suggests a "lymphocyte and distribution syndrome".