Jambur Ananth , John C. Pecknold , Nancy Van Den Steen , Frank Engelsmann
{"title":"Double-blind comparative study of clomipramine and amitriptyline in obsessive neurosis","authors":"Jambur Ananth , John C. Pecknold , Nancy Van Den Steen , Frank Engelsmann","doi":"10.1016/0364-7722(81)90077-1","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. The efficacy of clomipramine hydrochloride in severe obsessive compulsive neurosis (OCN) was compared with that of amitriptyline in a four week randomized double-blind trial.</p></span></li><li><span>2.</span><span><p>2. Clomipramine but not amitriptyline produced statistically significant improvement in the obsessive symptoms, depression and anxiety.</p></span></li><li><span>3.</span><span><p>3. The lack of significant effect of amitriptyline on anxiety and depression may be due to its inability to improve the primary obsessive symptoms.</p></span></li><li><span>4.</span><span><p>4. No serious adverse effects were encountered in either drug group.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":"5 3","pages":"Pages 257-262"},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90077-1","citationCount":"137","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in neuro-psychopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0364772281900771","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 137
Abstract
1.
1. The efficacy of clomipramine hydrochloride in severe obsessive compulsive neurosis (OCN) was compared with that of amitriptyline in a four week randomized double-blind trial.
2.
2. Clomipramine but not amitriptyline produced statistically significant improvement in the obsessive symptoms, depression and anxiety.
3.
3. The lack of significant effect of amitriptyline on anxiety and depression may be due to its inability to improve the primary obsessive symptoms.
4.
4. No serious adverse effects were encountered in either drug group.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
