Effect of intravenous infusion of OKY-1581 (Sodium-(E)-3-[4-(3-pyridylmethyl)phenyl]-2-methylacrylate) on circulatory thromboxane A2 and prostacyclin levels in anaesthetized baboon
Ashim C. Roy, P.Ganesan Adaikan, Sultan M.M. Karim
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引用次数: 6
Abstract
OKY-1581, a known inhibitor of thromboxane biosynthesis, was infused intravenously in six healthy baboons anaesthetized with pentobarbitone sodium. Systemic blood pressure and heart rate were continuously recorded and the levels of plasma thromboxane B2 and 6-keto PGF1α were determined in samples taken before, during and after the infusion of OKY-1581. Following the infusion of OKY-1581 plasma level of TXB2 decreased and 6-keto PGF1α level increased in most animals. However, these changes were not consistent or dose-related and no significant effect was seen in some animals.
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