[Approach to ethanol metabolism in man by studying the concentration-time curves of ethanol, free enzyme and plasma acetate (author's transl)].

Toxicological European research. Recherche europeenne en toxicologie Pub Date : 1982-03-01
R Bruno, A Iliadis, Y Santoni, A Botta, B Mariotti, M J Treffot, J P Cano
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Abstract

The use of a pharmacokinetic model characterized by a new theoretical approach of the enzymatic reaction allows to account for ethanol concentration-time curve (after oral administration in man) and to simulate the evolution of free enzyme concentration. The interpretation of the various phases observed during these kinetics (ethanol, free enzyme) and plasma acetate kinetics (performed in the same study) constitutes an original approach to ethanol metabolism.

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[通过研究乙醇、游离酶和血浆醋酸盐的浓度-时间曲线探讨人体内乙醇代谢[作者译]。
使用以酶促反应的新理论方法为特征的药代动力学模型，可以解释乙醇浓度-时间曲线(在人口服后)，并模拟游离酶浓度的演变。在这些动力学(乙醇，游离酶)和血浆醋酸酯动力学(在同一研究中进行)中观察到的各种相的解释构成了乙醇代谢的原始方法。
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Toxicological European research. Recherche europeenne en toxicologie
Toxicological European research. Recherche europeenne en toxicologie
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