[Pharmacokinetics of arsenic trioxide in the mouse].

Abstract

Considering the diversity of previous observations given by literature about the metabolic fate or arsenic, the authors using a radioactive tracer, study the pharmacokinetics of that arsenical derivative after giving the mouse a non toxic dose. By the oral route, this compound is quickly absorbed and resorbed. The elimination process mainly occurs by renal route then by the faecal route. The blood results or the concentrations in the tissues do not reveal any retention process though the latter always rise above blood levels. During the first two hours the concentrations in the thymus seem to be particularly interesting.