[Immunotherapy of burns--animal experiments].

Abstract

Immunologic changes are a component of the pathophysiology of severe burns. The effect of the burn toxin can be reduced by immunologic mechanism. The antigen elimination by immunologic defense mechanism additionally to the necrectomy was discussed. A significant therapeutic effect after standardised burn in the animal mouse model showed the application of heterologous antibodies against the burn antigen and the specific immunostimulation. The antibody titre and the number of lymphocytes which bind burn toxin were investigated. The animal experimental results show the real chances of the antigen elimination by passive immunisation respectively immunostimulation. Immunosuppressive influence by therapeutic measures must be avoided.