Elevation of thermoregulatory vasodilatation threshold in the rat after capsaicin treatment.

F Obál, F Bari, G Benedek, F Obál
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Abstract

In control and capsaicin-treated (300 mg/kg) rats tail skin vasodilatation was studied while the body temperature was raised to 38 degrees C, 39 degrees C or 40 degrees C and held at these levels. In the capsaicin-treated rats, at 38 degrees C vasodilatation was weaker than in the controls but at temperatures of 39 degrees C and 40 degrees C a delayed increase in tail vasodilatation occurred to the level observed in the controls. It is concluded that the threshold of vasodilatation response to heat is elevated after capsaicin treatment.

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辣椒素治疗后大鼠热调节性血管舒张阈值升高。
在对照组和辣椒素(300 mg/kg)处理的大鼠中,当体温升高到38℃、39℃和40℃并保持在这些水平时,研究了尾部皮肤血管舒张。在辣椒素处理的大鼠中,在38摄氏度时血管扩张比对照组弱,但在39摄氏度和40摄氏度的温度下,尾部血管扩张的延迟增加出现在对照组中观察到的水平。结论:辣椒素处理后,热血管舒张反应阈值升高。
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