[Effect of low pH values on the infectivity and neuraminidase activity of human and animal strains of influenza virus type A].

Abstract

The influence of acidic pH on the infectivity and neuraminidase activity of human, equine and avian type A influenza virus strains has been studied. Following exposure to pH 3 human and equine strains lost their infectivity completely, whereas all investigated strains of the subtypes Hav6N2 and Hav7Neq2 retained a certain amount of infectivity. In contrast to human and equine strains the avian strains retained also 38% of their original neuraminidase activity after acidic treatment. Partial retention of infectivity and the relative stability of the neuraminidase following exposure to acidic pH are supposed to be linked together in avian influenza virus strains implicating neuraminidases for their ability to prevent the aggregation of virions.