{"title":"Discriminative stimulus properties of cocaine related to an anxiogenic action","authors":"Gary T. Shearman, Harbans Lal","doi":"10.1016/0364-7722(81)90005-9","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. Male hooded rats were trained to discriminate the anxiogenic action of phentylenetetrazol by responding for food reinforcement with a lever located on one side of a food cup 15 min following a 20 mg/kg pentylenetetrazol injection and responding with the lever located on the alternate side of the food cup 15 min following a 1 ml/kg saline injection.</p></span></li><li><span>2.</span><span><p>2. Cocaine (20 mg/kg) but not diazepam (5 mg/kg) nor haloperidol (0.16 or 0.64 mg/kg) significantly generalized to the pentylenetrazol discriminative stimulus.</p></span></li><li><span>3.</span><span><p>3. Diazepam (5 mg/kg) but not haloperidol (0.16 or 0.64 mg/kg) significantly antagonized the discriminative stimuli produced by pentylenetetrazol and cocaine.</p></span></li><li><span>4.</span><span><p>4. These data suggest that cocaine produces discriminative stimulus that is related to its anxiogenic action.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90005-9","citationCount":"44","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in neuro-psychopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0364772281900059","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 44
Abstract
1.
1. Male hooded rats were trained to discriminate the anxiogenic action of phentylenetetrazol by responding for food reinforcement with a lever located on one side of a food cup 15 min following a 20 mg/kg pentylenetetrazol injection and responding with the lever located on the alternate side of the food cup 15 min following a 1 ml/kg saline injection.
2.
2. Cocaine (20 mg/kg) but not diazepam (5 mg/kg) nor haloperidol (0.16 or 0.64 mg/kg) significantly generalized to the pentylenetrazol discriminative stimulus.
3.
3. Diazepam (5 mg/kg) but not haloperidol (0.16 or 0.64 mg/kg) significantly antagonized the discriminative stimuli produced by pentylenetetrazol and cocaine.
4.
4. These data suggest that cocaine produces discriminative stimulus that is related to its anxiogenic action.
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