[Albumin and IGG in the CSF as demonstration of blood-brain barrier damage and of immune response within the CNS (author's transl)].

Abstract

The Cerebrospinal Fluid (CSF) and the serum of 102 neurological patients was studied in subgroups according to diagnostic criteria. The Blood-Brain-Barrier (BBB) is more severely damaged in cases of cerebral tumors and haemorragic cerebral diseases; synthesis of IgG within the CNS is more pronounced in Multiple Sclerosis (MS) patients in comparison with patients of other groups. The ratio IgG/PT in CSF is very high in MS patients. Considering the degree of increase of the IgG Index and of the ratio IgG/PT in CSF the Authors found the highest values in MS and this is typical of such disease. The degree of increase of the ratio CSF albumin/serum albumin showed highest values in patients with tumors or with haemorragic cerebral diseases.