[Comparison of the effects of absorption of aminophenazone or propyphenazone combined with sodium nitrite on the incidence and early appearance of tumors in the rat].

Abstract

Formation of nitrosamines, after absorption of nitrite and secondary or tertiary amines in the gastro-intestinal tract, is used as a chemical test of carcinogenicity in the Rat. We have confirmed the carcinogenic power of a tertiary amine association: aminophenazone, and sodium nitrite giving dimethyl-nitrosamine in Sprague Dawley rats: both substances are administered at low and high concentrations in drinking water. We have studied simultaneously, the propyphenazone/sodium nitrite association in the same experimental conditions without carcinogenic power: --treatment duration: thirty weeks, --study duration: two years with observation of carcinogenic reactions, --verification of data: control and substances given independently.