{"title":"Chronic haloperidol treatment fails to alter the anorexic actions of dopaminergic agonists and cholinergic drugs","authors":"Martin D. Hynes , Harbans Lal","doi":"10.1016/0364-7722(81)90079-5","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. Experimental rats were chronically treated with haloperidol and tested with dopaminergic and cholinergic drugs for their anorexic effects.</p></span></li><li><span>2.</span><span><p>2. All of the test drugs significantly reduced the compulsive eating that results from food deprivation.</p></span></li><li><span>3.</span><span><p>3. Chronic haloperidol failed to change sensitivity of the animals to dopaminergic or cholinergic drugs. There was a trend towards an increase in sensitivity to a peripheral effect of a cholinergic drug.</p></span></li><li><span>4.</span><span><p>4. In contrast to the present data, sensitivity to dopaminergic drugs in producing locomotor stimulation and stereotypy is increased after chronic haloperidol. These experiments suggest that alteration in neurotransmitter functioning after chronic neuroleptics markedly differs in different neurobehavioral systems.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90079-5","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in neuro-psychopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0364772281900795","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
1.
1. Experimental rats were chronically treated with haloperidol and tested with dopaminergic and cholinergic drugs for their anorexic effects.
2.
2. All of the test drugs significantly reduced the compulsive eating that results from food deprivation.
3.
3. Chronic haloperidol failed to change sensitivity of the animals to dopaminergic or cholinergic drugs. There was a trend towards an increase in sensitivity to a peripheral effect of a cholinergic drug.
4.
4. In contrast to the present data, sensitivity to dopaminergic drugs in producing locomotor stimulation and stereotypy is increased after chronic haloperidol. These experiments suggest that alteration in neurotransmitter functioning after chronic neuroleptics markedly differs in different neurobehavioral systems.
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