{"title":"Effects of prostaglandins E1 and E2 on the in vitro production of immunoglobulin by human peripheral blood lymphocytes","authors":"J.V. Dunnes, B. Foss, T. Leung, R.J.R. McKendry","doi":"10.1016/0161-4630(81)90074-4","DOIUrl":null,"url":null,"abstract":"<div><p>The effects of PGE<sub>2</sub> and PGEl on the response of human peripheral blood lymphocytes to Pokeweed mitogen were studied.</p><p>Addition of PGE2 inhibited IgM production. This effect was augmented by treating the lymphocytes with 2.0 ug/ml of Indomethacin. Addition of PGE, alone had little effect but augmentation of IgM production was seen in cultures where the lymphocytes had been treated with Indomethacin and PGEl then added. The results suggest that PGE<sub>1</sub>/E<sub>2</sub> have a small but measurable effect on in vitro IgM production.</p></div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"6 4","pages":"Pages 419-425"},"PeriodicalIF":0.0000,"publicationDate":"1981-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90074-4","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins and medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0161463081900744","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 7
Abstract
The effects of PGE2 and PGEl on the response of human peripheral blood lymphocytes to Pokeweed mitogen were studied.
Addition of PGE2 inhibited IgM production. This effect was augmented by treating the lymphocytes with 2.0 ug/ml of Indomethacin. Addition of PGE, alone had little effect but augmentation of IgM production was seen in cultures where the lymphocytes had been treated with Indomethacin and PGEl then added. The results suggest that PGE1/E2 have a small but measurable effect on in vitro IgM production.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
