Nocturnal angina and sleep

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI:10.1016/0364-7722(81)90010-2

Giovanni Battista Cassano, Carlo Maggini, Mario Guazzelli

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引用次数: 9

Abstract

1.
1. Nocturnal sleep and electro cardiographic patterns were continously investigated in 20 male patients suffering from nocturnal angina attacks. Sleep pattern was severely disturbed regardless of the presence of ischemic episodes. Sleep Time was reduced because of a large Awakening Time and an Early Final Awakening. Stages 1 and 2 were increased and stages 3, 4 and, less markedly, REM were reduced.
2.
2. Ischemic episodes were more frequently observed between 24:00 and 04:00 without any significant relationship to the sleep stages, thus suggesting the influence of a cronobiologic factor on the distribution of ischemic attacks during the night.
3.
3. Ischemic episodes observed during the hemodynamic monitoring did not show any significant relation to the increase of myocardial oxygen consumption. This observation, together with the lack of relation between REM sleep and ischemic episodes during the night, seem to support the hypothesis of a reversible coronary spasm in the pathogenesis of nocturnal angina.

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夜间心绞痛和睡眠

1.1. 对20例男性夜间心绞痛患者的夜间睡眠和心电图模式进行了连续调查。无论是否存在缺血性发作，睡眠模式都受到严重干扰。睡眠时间减少了，因为一个大的觉醒时间和一个早期的最终觉醒。第1、2期增加，第3、4期和较不明显的REM减少。24 - 04:00期间缺血性发作更为频繁，且与睡眠阶段无明显关系，提示存在睡眠生物学因素对夜间缺血性发作分布的影响。血流动力学监测中观察到的缺血发作与心肌耗氧量的增加没有明显的关系。这一观察结果，加上REM睡眠与夜间缺血性发作之间缺乏关系，似乎支持了在夜间心绞痛发病机制中可逆性冠状动脉痉挛的假设。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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