Atherosclerosis and dissipative structures.

Scientia Sinica Pub Date : 1981-09-01
K Lu, B F Zheng
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Abstract

The theory of dissipative structure is applied to the study of atherosclerosis. An autocatalytic theoretical model is suggested. The behaviors of the model are in agreement with the facts of experimental atherosclerosis. We predict the high effectiveness of combinative therapy for atherosclerosis with drugs affecting protein metabolism and lipid metabolism. It was verified by animal experimentation. Further possible developments are briefly discussed. This work is the theoretical foundation of the Multi-Risk Factor Intervention trial (MRFIT) which is popularized clinically in its beginning all over the world.

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动脉粥样硬化和耗散结构。
将耗散结构理论应用于动脉粥样硬化的研究。提出了一种自催化理论模型。模型的行为与实验动脉粥样硬化的事实一致。我们预测影响蛋白质代谢和脂质代谢的药物联合治疗动脉粥样硬化的有效性很高。动物实验证实了这一点。简要讨论了进一步可能的发展。该工作为多危险因素干预试验(MRFIT)的临床推广奠定了理论基础。
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