The suppressive effect of human chorionic gonadotropin of various preparations on lymphocyte blastogenesis in vitro.

Abstract

The effect of human chorionic gonadotropin (hCG) of different purities from various source (eg. normal pregnancy urine, normal chorionic tissue, hydatidiform mole and vesicular fluid of hydatidiform mole) on the transformation of peripheral human lymphocytes was studied. All kinds of crude preparations of hCG suppressed lymphocyte transformation in a dose-dependent manner, in the phytohemagglutinin-induced stimulation. In addition, purified products of hCG have been shown a more inhibitory capacity in vitro. The inhibitory activity, however, was found not to be correlated with the gonadotropic activity of the various preparations, whereas this experiment, implicating which was compared to the content of sialic acid (N-acetylneuraminic acid) of different preparations.