An investigation of the interaction between the reinforcing properties of food and ethanol using the place preference paradigm

Robert B. Stewart, Larry A. Grupp
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引用次数: 50

Abstract

  • 1.

    1. For three groups of rats, intraperitoneal injections of either 250, 500, or 1000 mg/kg ethanol were paired with a distinctive environment and later a choice was offered between that environment and one that had previously been associated with saline injections.

  • 2.

    2. For a second set of three groups of animals the identical procedure was followed except that food was available in both the environment paired with ethanol and the one paired with saline.

  • 3.

    3. The rats showed no preference or aversion for the environment paired with the 250 mg/kg dose either when the drug was given alone or when combined with the availability of food. No preference or aversion for the 500 mg/kg dose was indicated when the drug was given alone, but the same dose combined with food was preferred to food plus saline. The 1000 mg/kg dose was found to be aversive when given by itself, yet the same dose was neither aversive nor preferred when combined with the availability of food.

  • 4.

    4. These findings suggest that ethanol can interact with food, a positive reinforcer, in ways that cannot be predicted from the effect of the drug when presented alone.

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利用位置偏好范式研究食物和乙醇强化特性之间的相互作用
1.1. 对于三组大鼠,分别腹腔注射250mg、500mg或1000mg /kg的乙醇,并与不同的环境配对,然后在该环境和先前与生理盐水注射相关的环境之间进行选择。第二组的三组动物遵循了相同的程序,只是食物在乙醇和盐水两种环境中都有。无论是单独给药还是与食物一起给药,大鼠都没有表现出对250 mg/kg剂量的环境的偏好或厌恶。单独给药时,对500 mg/kg剂量没有偏好或厌恶,但相同剂量与食物联合使用比食物加生理盐水更受欢迎。当单独给药时,1000mg /kg的剂量被发现是令人厌恶的,但当与食物的可得性结合时,同样的剂量既不令人厌恶,也不受欢迎。这些发现表明,乙醇可以与食物(一种正强化物)相互作用,其作用方式无法从单独呈现的药物效果中预测出来。
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