Changes of fucose content in the surface glycoproteins of macrophages induced by golden hamster transplantable melanomas

K. Kozłowska, B. Żurawska-Czupa
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Abstract

The influence of two kinds of transplantable melanomas on the content of fucose in the surface glycoproteins of hamster peritoneal macrophages was studied.

An increase in the content of fucose, more prominent in surface material of macrophages from animals with melanotic melanoma was found.

It has been suggested that this phenomenon is connected with the neoplastic process, and that the different susceptibility of the macrophages from experimental animals to macrophage inhibitory factor (MIF) is related to changes in the content of fucose in the surface glycoproteins.

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金仓鼠可移植黑色素瘤诱导巨噬细胞表面糖蛋白病灶含量的变化
研究了两种可移植黑色素瘤对仓鼠腹腔巨噬细胞表面糖蛋白含量的影响。发现黑素瘤动物巨噬细胞中病灶含量增加,且在表面物质中更为突出。这一现象可能与肿瘤发生过程有关,实验动物巨噬细胞对巨噬细胞抑制因子(macrophage inhibitory factor, MIF)的不同易感性可能与表面糖蛋白中病灶含量的变化有关。
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