{"title":"Morphopharmacological analysis of the carcinogenic properties of N-methyl-N′-nitro-N-nitrosoguanidine","authors":"V.K. Gurkalo, N.J. Volfson","doi":"10.1016/S0014-4908(80)80026-3","DOIUrl":null,"url":null,"abstract":"<div><p>The modifying influence of atropine and reserpine on N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) induction of stomach tumors was studied in experiments on 120 randombred male white rats. At the same time, pharmacological analysis of the mechanism of the carcinogenic action of MNNG was carried out. Atropine stimulated and reserpine markedly inhibited the carcinogenic effect of MNNG. MNNG interference altered the specific effects of amphetamine and phenobarbital. These alterations are due to the MNNG damage of the permeability of the presynaptic membrane of the central adrenergic structures. The leading role of adrenergic influences on the processes of carcinogenic transformation of stomach cell processes is discussed.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"18 6","pages":"Pages 353-359"},"PeriodicalIF":0.0000,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80026-3","citationCount":"21","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimentelle Pathologie","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0014490880800263","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 21
Abstract
The modifying influence of atropine and reserpine on N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) induction of stomach tumors was studied in experiments on 120 randombred male white rats. At the same time, pharmacological analysis of the mechanism of the carcinogenic action of MNNG was carried out. Atropine stimulated and reserpine markedly inhibited the carcinogenic effect of MNNG. MNNG interference altered the specific effects of amphetamine and phenobarbital. These alterations are due to the MNNG damage of the permeability of the presynaptic membrane of the central adrenergic structures. The leading role of adrenergic influences on the processes of carcinogenic transformation of stomach cell processes is discussed.
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