Effect of dietary sucrose in humans on blood uric acid, phosphorus, fructose, and lactic acid responses to a sucrose load.

Abstract

10 men and 9 women consumed diets that were identical, except for the 30% of the calories derived from either starch or sucrose, for 6 weeks in a crossover design. Of the total calories, 10% were given at breakfast and 90% at dinner. A sucrose load of 2 g/kg body weight was administered 1 week before and during the last week of both dietary periods. Blood was drawn before (fasting) and 0.5, 1, 2 and 3 h after the sucrose load. Serum uric acid was significantly higher (p < 0.01) and blood fructose significantly lower (p < 0.05) before and at all times after the sucrose load when subjects consumed the sucrose versus the starch diet. Levels of serum inorganic phosphorus and blood lactic acid were not affected by kind of carbohydrate in the diet.