Elisabeth Friess, Klaus Wiedemann, Axel Steiger, Florian Holsboer
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引用次数: 105
Abstract
This review article summarizes the major findings about the interactions of human sleep structure and the hypothalamo-pituitary-adrenocortical (HPA) system under physiological and pathophysiological conditions, including studies that probe the sleep effects of systemically administered HPA hormones.
Human sleep is regulated by a concerted action of various signal compounds acting at sleep-generating neurons whose central organization is not yet fully understood. During nocturnal sleep the endocrine system is remarkably active, the longest established finding being that growth hormone (GH) release is associated with the initiation of sleep and that there is a steep morning rise of cortisol (Weitzman et al., 1966; Takahashi et al., 1968). Moreover, the effects of exogenously administered corticosteroids and of their excessive endogenous release (e.g. Cushing's disease) were recognized more than 20 years ago.
本文综述了在生理和病理生理条件下人类睡眠结构与下丘脑-垂体-肾上腺皮质(HPA)系统相互作用的主要研究成果,包括系统给药HPA激素对睡眠影响的研究。人类的睡眠是由各种信号化合物协同作用于产生睡眠的神经元来调节的,这些神经元的中枢组织尚未完全了解。在夜间睡眠时,内分泌系统非常活跃,最早的发现是生长激素(GH)的释放与睡眠的开始有关,并且皮质醇在早晨急剧上升(Weitzman等人,1966;Takahashi et al., 1968)。此外,外源性给药皮质类固醇及其内源性过度释放(如库欣病)的影响在20多年前就已被认识到。