{"title":"Effects of adenosine on chronotropic responses of rat atria to alpha and beta adrenergic stimulation.","authors":"O A Gende","doi":"10.3109/13813459309046987","DOIUrl":null,"url":null,"abstract":"<p><p>The chronotropic response of rat atria to beta adrenergic stimulation required higher concentrations of agonist in the presence of adenosine. This anti beta-adrenergic effect could attenuate the tachycardia induced by the increased sympathetic tone during cardiac ischemia. The sensitivity to alpha adrenergic stimulation did not change in the presence of adenosine.</p>","PeriodicalId":77008,"journal":{"name":"Archives internationales de physiologie, de biochimie et de biophysique","volume":"101 6","pages":"329-31"},"PeriodicalIF":0.0000,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/13813459309046987","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives internationales de physiologie, de biochimie et de biophysique","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3109/13813459309046987","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The chronotropic response of rat atria to beta adrenergic stimulation required higher concentrations of agonist in the presence of adenosine. This anti beta-adrenergic effect could attenuate the tachycardia induced by the increased sympathetic tone during cardiac ischemia. The sensitivity to alpha adrenergic stimulation did not change in the presence of adenosine.
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