Neurotransmitter control of growth hormone secretion in humans.

E Ghigo, E Arvat, J Bellone, J Ramunni, F Camanni
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引用次数: 33

Abstract

Growth hormone secretion is mainly regulated by the interplay of GHRH and somatostatin, two specific hypophysiotrophic neurohormones. In addition to GHRH and somatostatin, many neurotransmitters and neuropeptides influence GH secretion mainly by acting at the hypothalamic level. This paper focuses on the stimulatory role of acetylcholine, arginine and galanin as well as on the inhibitory influence of catecholamines which is mediated by the activation of beta-adrenergic receptors. Attention will be given to the age-related changes in the neural control of GH secretion from childhood to old age.

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神经递质对人类生长激素分泌的控制。
生长激素的分泌主要受GHRH和生长抑素这两种特殊的垂体营养神经激素的相互作用调节。除了GHRH和生长抑素外,许多神经递质和神经肽主要通过作用于下丘脑水平来影响GH的分泌。本文重点介绍了乙酰胆碱、精氨酸和甘丙氨酸的刺激作用,以及儿茶酚胺通过激活β -肾上腺素能受体介导的抑制作用。注意将给予年龄相关的变化在神经控制GH分泌从童年到老年。
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