Detection of mutagenicity of diphenyl ether herbicides in Salmonella typhimurium YG1026 and YG1021

Mutation Research Letters Pub Date : 1995-01-01 DOI:10.1016/0165-7992(95)90069-1

Atsuko Oguri , Kiyoka Karakama , Nobuhiko Arakawa , Takashi Sugimura , Keiji Wakabayashi

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引用次数: 11

Abstract

Three kinds of diphenyl ether herbicides, 4-nitrophenyl 2,4,6-trichlorophenyl ether (CNP, chlornitrofen), 2,4-dichlorophenyl 3-methoxy-4-nitrophenyl ether (chlomethoxynil) and 2,4-dichlorophenyl 3-methoxycarbonyl-4-nitrophenyl ether (bifenox), were tested for mutagenicity in Salmonella typhimurium YG1026 and YG1021, which have high nitroreductase activity, and also in S. typhimurium TA100 and TA98. CNP and chlomethoxynil showed mutagenicity in S. typhimurium YG1026, without S9 mix, inducing 50 and 304 revertants per μg. These mutagenicities were suppressed by the addition of S9 mix. CNP and chlomethoxynil were also mutagenic to YG1021 with and without S9 mix, and their mutagenicities were lower than those to YG1026. On the other hand, bifenox was mutagenic to YG1026 only with S9 mix, inducing 3.0 revertants per μg. These three herbicides showed no mutagenicity in S. typhimurium TA100 and TA98 either with or without S9 mix.

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二苯醚除草剂对鼠伤寒沙门菌YG1026和YG1021致突变性的检测

对硝基还原酶活性较高的鼠伤寒沙门氏菌YG1026和YG1021以及鼠伤寒沙门氏菌TA100和TA98进行了4-硝基苯基2,4,6-三氯苯基醚(CNP，氯硝基芬)、2,4-二氯苯基3-甲氧基-4-硝基苯基醚(氯甲氧基)和2,4-二氯苯基3-甲氧基羰基-4-硝基苯基醚(联苯醚)3种二苯醚除草剂的致突变性试验。CNP和氯甲氧虫腈对鼠伤寒沙门氏菌YG1026具有致突变性，在不添加S9的情况下，每μg分别诱导50和304个应答体。这些诱变性被添加S9混合物抑制。CNP和氯甲氧虫腈对YG1021也有诱变作用，但诱变率低于对YG1026的诱变率。另一方面，联苯醚仅与S9混合对YG1026具有诱变作用，每μg诱导3.0个应答物。3种除草剂对鼠伤寒沙门氏菌TA100和TA98均无致突变性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mutation Research Letters

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