Milena Sedliaková, Viera Slezáriková, Frantisšek Miroslav Piršel
{"title":"Inducible stable DNA replication of Escherichia coli tolerates unexcised pyrimidine dimers in an uvr-dependent manner","authors":"Milena Sedliaková, Viera Slezáriková, Frantisšek Miroslav Piršel","doi":"10.1016/0165-7992(95)90062-4","DOIUrl":null,"url":null,"abstract":"<div><p>Damage-inducible DNA replication (iSDR) was followed in UV-irradiated <em>E. coli uvr</em><sup>+</sup> and <em>uvr</em>B5. Owing to the inhibition of dimer excision in the former (caused by the metabolic treatment), both contained similar amounts of unexcised dimers. Since iSDR took place in <em>uvr</em><sup>+</sup> but not in <em>uvr</em>B5 cells, it is concluded that the <em>uvr</em> system can tolerate unexcised dimers through the recombinogenic iSDR.</p></div>","PeriodicalId":100934,"journal":{"name":"Mutation Research Letters","volume":"346 1","pages":"Pages 9-13"},"PeriodicalIF":0.0000,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0165-7992(95)90062-4","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mutation Research Letters","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0165799295900624","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
Damage-inducible DNA replication (iSDR) was followed in UV-irradiated E. coli uvr+ and uvrB5. Owing to the inhibition of dimer excision in the former (caused by the metabolic treatment), both contained similar amounts of unexcised dimers. Since iSDR took place in uvr+ but not in uvrB5 cells, it is concluded that the uvr system can tolerate unexcised dimers through the recombinogenic iSDR.
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