{"title":"Heavy metals enhance the reactivation of nitrous acid-treated adenovirus in HeLa cells","authors":"S.M. Piperakis","doi":"10.1016/0165-7992(95)90063-2","DOIUrl":null,"url":null,"abstract":"<div><p>Treatment of HeLa cells with cadmium chloride and zinc chloride increases the survival rate of nitrous acid-treated adenovirus 2 (ade2). This increase is maximal if the time interval between cell treatment and virus infection is delayed by 36 h. The induction process requires protein synthesis only during the 3-h period immediately following treatment; cycloheximide does not prevent the expression of enhanced reactivation if added to the cells after this time.</p></div>","PeriodicalId":100934,"journal":{"name":"Mutation Research Letters","volume":"346 1","pages":"Pages 15-18"},"PeriodicalIF":0.0000,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0165-7992(95)90063-2","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mutation Research Letters","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0165799295900632","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Treatment of HeLa cells with cadmium chloride and zinc chloride increases the survival rate of nitrous acid-treated adenovirus 2 (ade2). This increase is maximal if the time interval between cell treatment and virus infection is delayed by 36 h. The induction process requires protein synthesis only during the 3-h period immediately following treatment; cycloheximide does not prevent the expression of enhanced reactivation if added to the cells after this time.
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