Control of inflammatory processes by cell-impermeable inhibitors of phospholipase A2.

S Yedgar, P Dan, A Dagan, I Ginsburg, I S Lossos, R Breuer
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引用次数: 12

Abstract

Cell-impermeable inhibitors of phospholipase A2 were prepared by linking inhibiting molecules to macromolecular carriers which prevent the inhibitor's internalization. These preparations inhibit the release of oxygen reactive species from neutrophils and cell death induced by inflammatory agents, as well as bleomycin-induced lung injury.

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磷脂酶A2细胞不渗透抑制剂控制炎症过程。
通过将抑制分子连接到防止抑制剂内化的大分子载体上,制备了细胞不渗透磷脂酶A2抑制剂。这些制剂抑制中性粒细胞释放氧活性物质和炎症剂诱导的细胞死亡,以及博莱霉素诱导的肺损伤。
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